I would assume it is a vid card driver issue you are having maybe, upgrading that usually helped alot of games out in NT4, but some just plain would not run.
In The Zone last night I saw someone with instructions on playing without a CD. It looked like you needed two programs - one that converted your CD into a file on your hard drive, and then another that run it as a ‘virtual CD’. I wrote the info down but don’t have it with me right now. I will try it tonight and let you know if it works.
Sadly, the v133 patch does not fix everything and there are still a lot logical errors to be dealt with. For instance, for some reason I can still have more than one AA gun in the same territory. It is not these errors that enrage me (anybody can avoid these problems by just not performing them), but the horrid AI in the game and the sudden crashes (the later being somewhat corrected in v133).