Doubtful. The only two ways I see the war ending without the US are:
1940. Holland, Belgium, Denmark, Norway, and Poland, of course, have been conquered. Britain and France (Chamberlain is the PM at this point), sue for peace. Britain and France have to pay reparations (especially heavy reparations for France), and hand over various colonies. Plus, they have to recognize Hitler’s conquests in Europe. Possibly, the French would have to hand back Alsace- Lorraine as well. Hitler would most likely consider this to be avenging the Versailles Treaty. This results in Britain and France becoming second to Germany, but still powers to be reckoned with. Chamberlain wanted peace, so he may have grudgingly accepted Nazi occupied Norway and Holland (unlikely), and the French were desperate to save their homeland. Neither would fight alone, so they’d accept peace. Hitler would then attack the USSR, possibly with Anglo-French support.
Mid-late 1940s.
Sealion has not taken place, and the Germans have attacked the USSR. They wear each other out, but the USSR has a nearly limitless supply of men and resources. It would have been much bloodier, but eventually, the Russians would’ve gotten the upper hand, and the war would play out as it did- except that since the US never got involved in D-Day, the British were too weak to open up a second front, so most of Europe would’ve been liberated by the Russians, and therefore fallen into the Soviet bloc after the war. In fact, NATO and the Western bloc may not have existed at all, since Britain’s voice would have counted for far less in the post-war world, and Stalin would control Europe, effectively.